High resolution genotyping of complex immune regions
Fast and accurate high resolution genotyping of complex immune regions is critical to improving transplant outcomes and understanding disease associations.
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Scisco Genetics Inc. is committed to providing the highest possible standard of testing to our clients
Therefore, we have implemented a quality assurance program to ensure continuous improvement in our performance and accurate and reliable test results for our customers. Given good quality DNA samples, our quality metric is to obtain 100% accuracy in typing.
Scisco Services™
Scisco Genetics typing solutions for HLA, KIR, Fc, MIC AB and more.
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ScisGo™ Kits
Phased 3-field HLA typing in a single assay using proven Scisco Genetics technology.
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ScisCloud Software™
Software products for laboratory workflow, typing analysis and data management.
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NGS
Next Generation Sequencing
Scisco Genetics has developed a system using the Illumina Miseq, which is based on a sequencing-by-synthesis approach utilizing fluorescently labeled reversible terminator nucleotides. After assay specific amplification, samples are tagged with unique indexes and pooled together and applied to the MiSeq device where they are amplified as individual clusters and sequenced using universal sequencing primers. The result is several million reads that can be analyzed using ScisCloud™ to report unambiguous HLA allele types and KIR haplotypes for scores to hundreds of individual samples simultaneously.
Our quality assurance program has been assessed and approved by the American Society for Histocompatibility and Immunogenetics (ASHI) and the Clinical Laboratory Improvements Amendments (CLIA).
Company News
Latest company news and publications
HLA, Sep 2019
Comparison of sequence-specific oligo-nucleotide probe vs NGS for HLA-A, B, C, DRB1, DRB3/B4/B5, DQA1, DQB1, DPA1, and DPB1 typing
We compare a NGS technology with SSOP for accuracy, effort, turnaround time, and level of resolution for genotyping of 11 HLA loci among 289 specimens from five clinical laboratories. With few exceptions, SSOP generated ambiguous results while NGS provided unambiguous three-field allele assignments. This study provides compelling evidence that, although not viable for STAT typing of deceased donors, a single-pass NGS HLA typing method has direct application for solid organ transplantation.
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Human Immunology, Dec 2015
An integrated genotyping approach for HLA and other complex genetic systems
The development and testing of the Integrated Genotyping System (IGS), which has been designed to specifically address the challenges associated with the adoption of NGS in clinical laboratories. The results are discussed with respect to their applications in the clinical setting and consequent potential for advancing precision medicine.
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Journal of Clinical Investigation, Sep 2014
FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial
NGS typing identified 166 class II alleles, including 9 novel sequences with greater than 99% accuracy for DRB1 and DQB1 genotypes and elimination of diploid ambiguities through in-phase sequencing demonstrated the robust reliability of the NGS HLA genotyping reagents and analysis software employed in this study.
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